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Translational Medicine / 转化医学cfDNA Fragmentomics

Matthew Meyerson

MD, PhD

🏢Dana-Farber Cancer Institute / Harvard Medical School🌐USA

Professor of Pathology and Medical Oncology

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👥Biography 个人简介

Matthew Meyerson has made foundational contributions to cancer genomics and the application of cell-free DNA fragmentation patterns for non-invasive cancer detection. His laboratory pioneered genome-wide fragmentation profiling approaches that leverage nucleosome positioning to infer chromatin accessibility from plasma cfDNA, enabling tissue-of-origin identification. His work on lung cancer driver gene discovery and integrative genomic analysis has established frameworks now applied to fragmentomics-based multi-cancer screening.

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🧪Research Fields 研究领域

cfDNA fragmentation patterns
Cancer genomics
Lung cancer driver discovery
Chromatin accessibility inference
Genome-wide fragmentation profiling

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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