Sarkis Mazmanian

Sarkis Mazmanian has made foundational discoveries on how commensal bacteria, particularly Bacteroides fragilis, modulate systemic immunity through polysaccharide A signaling, with direct relevance to anti-tumor immune responses and immunotherapy efficacy. His research demonstrates that specific microbial molecules can reprogram regulatory T cell populations that influence cancer immune evasion. His work bridges microbiology, immunology, and neuroscience in cancer contexts.