Maximilian Diehn
马克西米利安·迪恩
MD, PhD
Associate Professor of Radiation Oncology; Co-Director, Institute for Stem Cell Biology and Regenerative Medicine放射肿瘤学副教授；干细胞生物学与再生医学研究所联合主任
👥Biography 个人简介
Inventor of CAPP-Seq (Cancer Personalized Profiling by deep Sequencing), an ultrasensitive ctDNA detection method. His research focuses on ctDNA for lung cancer MRD detection, treatment response monitoring, and early relapse prediction, transforming post-treatment surveillance.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
CAPP-Seq Development
Invented CAPP-Seq, enabling detection of ctDNA at allele frequencies below 0.01%, revolutionizing sensitivity benchmarks for liquid biopsy in lung cancer and lymphoma.
Lung Cancer MRD
Demonstrated ctDNA-based MRD detection post-surgery and post-chemoradiotherapy predicts relapse months before clinical recurrence in non-small cell lung cancer.
Representative Works 代表性著作
Noninvasive identification of responses and resistance in metastatic lung cancer from plasma DNA
Cancer Discovery (2019)
Showed plasma ctDNA can track therapeutic responses and resistance mechanisms in real time during lung cancer treatment.
Sensitive tumour detection and classification using plasma cell-free DNA methylomes
Nature (2023)
Used cfDNA methylation profiling to achieve cancer detection and tissue-of-origin classification with high accuracy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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