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Translational Medicine / 转化医学Breast Cancer Stem Cells, IL-6, STAT3

Max Wicha

MD

🏢University of Michigan Rogel Cancer Center🌐USA

Distinguished Professor of Oncology

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Key Contributions

👥Biography 个人简介

Max Wicha at Michigan is a pioneer of breast cancer stem cell biology. His work identified IL-6 and STAT3 as key signaling molecules maintaining breast cancer stem cell self-renewal and demonstrated that paracrine feedback loops between cancer stem cells and their niche maintain the CSC state. His translational research on targeting CSC pathways with IL-6 pathway inhibitors, combined with conventional therapy, has generated clinical trial hypotheses now being tested.

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🧪Research Fields 研究领域

breast cancer stem cells
IL-6 pathway CSC
STAT3 cancer stem cells
CD44+CD24- CSC
feedback loop cancer stem cells

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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