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Translational Medicine / 转化医学T Cell Activation, CTLA-4 Biology

Matthew Krummel

MD

🏢University of California San Francisco🌐USA

Professor of Pathology

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Key Contributions

👥Biography 个人简介

Matthew Krummel at UCSF co-discovered the regulatory function of CTLA-4 as a brake on T cell activation alongside James Allison — work that contributed foundational understanding for the development of ipilimumab. His subsequent contributions to intravital imaging of T cell behavior in tumors have illuminated how T cells interact with cancer cells in vivo, advancing understanding of immune infiltration and exhaustion.

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🧪Research Fields 研究领域

CTLA-4
T cell activation
CD28 costimulation
tumor immunology
in vivo T cell imaging

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-02-01 | All information from publicly available academic sources

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