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Translational Medicine / 转化医学Reovirus Oncolytic Therapy, REOLYSIN

Matt Coffey

PhD

🏢Oncolytics Biotech🌐Canada

Chief Scientific Officer

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Key Contributions

👥Biography 个人简介

Matt Coffey has contributed to developing REOLYSIN (pelareorep) — a reovirus-based oncolytic therapy that preferentially replicates in RAS-activated cancer cells. His work on the mechanism of reovirus selectivity for RAS-mutant cancer cells and on clinical development of pelareorep in multiple cancer types including breast cancer and pancreatic cancer has advanced the oncolytic reovirus approach.

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🧪Research Fields 研究领域

reovirus oncolytic cancer
REOLYSIN pelareorep
RAS-activated cancer reovirus
oncolytic reovirus immunotherapy
pancreatic cancer reovirus

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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