Massimo Terzolo
马西莫·特尔佐洛
MD
Professor of Internal Medicine, Endocrinology Unit内科学教授，内分泌科
👥Biography 个人简介
Massimo Terzolo pioneered the EDP-M chemotherapy protocol for adrenocortical carcinoma and played a foundational role in the FIRM-ACT trial. He is a key contributor to European ACC guidelines and has extensively studied adrenal incidentaloma management and mitotane pharmacology.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
EDP-M Protocol Development
Designed and validated the etoposide-doxorubicin-cisplatin plus mitotane regimen that became the standard chemotherapy backbone for advanced adrenocortical carcinoma worldwide.
Adrenal Incidentaloma Guidelines
Led ESE/ENSAT guideline development for adrenal incidentalomas, providing evidence-based frameworks for workup and follow-up of incidentally discovered adrenal masses.
Adjuvant Mitotane Research
Contributed seminal observational data supporting adjuvant mitotane use after radical ACC resection, guiding post-surgical treatment decisions internationally.
Representative Works 代表性著作
Adjuvant Mitotane Treatment for Adrenocortical Carcinoma
New England Journal of Medicine (2007)
Multicenter study demonstrating significantly improved recurrence-free survival with adjuvant mitotane after radical ACC resection.
Combination Chemotherapy in Advanced Adrenocortical Carcinoma (FIRM-ACT)
New England Journal of Medicine (2012)
Co-investigator in this phase III RCT validating EDP-M as standard first-line chemotherapy for advanced ACC.
Management of Adrenal Incidentalomas: European Society of Endocrinology Clinical Practice Guideline
European Journal of Endocrinology (2016)
Authoritative guideline on evaluation and follow-up of the increasingly common incidental adrenal mass.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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