Massimo Pignatelli
马西莫·皮尼亚泰利
MD, PhD, FRCPath
Professor of Histopathology组织病理学教授
👥Biography 个人简介
Distinguished GI cancer pathologist and tumor microenvironment researcher. Seminal contributions to understanding E-cadherin and catenin expression in colorectal and gastric cancer progression, establishing these adhesion molecules as prognostic biomarkers and therapeutic targets.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
E-cadherin/Catenin Cancer Biology
Demonstrated that loss of E-cadherin and beta-catenin membrane expression in colorectal and gastric cancers correlates with invasion, metastasis, and poor prognosis, establishing them as clinically relevant pathologic biomarkers.
Tumor Microenvironment Characterization
Characterized stromal and immune cell components of the GI cancer microenvironment using multiplex IHC, identifying prognostic immune infiltration patterns relevant to immunotherapy response prediction.
Representative Works 代表性著作
Tumor Microenvironment Immune Profiling in Colorectal Cancer: Prognostic and Predictive Implications
Gut (2023)
Multiplex IHC profiling of TME immune subtypes in 800 colorectal cancers identified distinct immune desert, excluded, and inflamed phenotypes with differential outcomes.
E-cadherin and Catenin Expression as Biomarkers of Invasiveness in Gastric Adenocarcinoma
British Journal of Cancer (2021)
Systematic meta-analysis confirming prognostic value of E-cadherin loss across 4,200 gastric cancer patients.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
Antoni Ribas
UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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