Martin Fassnacht
马丁·法斯纳赫特
MD, PhD
Professor and Head of Endocrinology and Diabetology内分泌与糖尿病科主任教授
👥Biography 个人简介
Martin Fassnacht is a leading authority on adrenocortical carcinoma (ACC), coordinating the landmark FIRM-ACT trial that established EDP-M as a standard-of-care regimen. He chairs the European Network for the Study of Adrenal Tumors (ENSAT) and drives international ACC guidelines.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
FIRM-ACT Trial
Led the first randomized phase III trial in ACC, demonstrating superiority of EDP-M over streptozocin plus mitotane, defining the global chemotherapy standard for advanced disease.
Mitotane Optimization
Established therapeutic drug monitoring for mitotane and defined target plasma levels to maximize efficacy while managing toxicity in ACC patients.
ENSAT Registry & Guidelines
Built the European ENSAT database and co-authored international ACC management guidelines, enabling large-scale outcomes research across dozens of centers.
Representative Works 代表性著作
Combination Chemotherapy in Advanced Adrenocortical Carcinoma (FIRM-ACT)
New England Journal of Medicine (2012)
Landmark phase III RCT (n=304) establishing EDP-M as standard first-line chemotherapy for advanced ACC.
Management of Adrenocortical Carcinoma: European Society of Endocrinology Clinical Practice Guideline
European Journal of Endocrinology (2018)
Comprehensive evidence-based guideline covering diagnosis, staging, surgery, adjuvant therapy, and surveillance.
Prognostic Factors in Adrenocortical Carcinoma: A European Network for the Study of Adrenal Tumors Study
Journal of Clinical Oncology (2009)
Multi-center analysis identifying resection status and Ki-67 as key independent prognostic factors in ACC.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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