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Translational Medicine / 转化医学Adrenocortical Carcinoma, Mitotane Therapy

Martin Fassnacht

MD

🏢University Hospital Wurzburg🌐Germany

Professor of Endocrinology

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Key Contributions

👥Biography 个人简介

Martin Fassnacht at University Hospital Wurzburg is the world's foremost authority on adrenocortical carcinoma, having led the FIRM-ACT phase III trial defining mitotane-based chemotherapy regimens and co-leading the European Network for the Study of Adrenal Tumors (ENSAT). His work on mitotane pharmacokinetics, therapeutic drug monitoring, and adjuvant therapy recommendations has shaped global ACC management guidelines. He has contributed to the molecular characterization of ACC and identification of prognostic biomarkers. His comprehensive research program spanning epidemiology, pathology, systemic therapy, and molecular biology has defined the modern approach to ACC.

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🧪Research Fields 研究领域

adrenocortical carcinoma mitotane
FIRM-ACT trial ACC
ACC adjuvant therapy
European ACC guidelines
adrenal cortex cancer systemic treatment

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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