Markus Johansson
马库斯·约翰森
MD, PhD
Associate Professor of Oncology; Senior Consultant, Department of Radiation Sciences肿瘤学副教授；放射科学系高级顾问
👥Biography 个人简介
Markus Johansson, MD, PhD is a translational oncologist and epidemiologist whose work has illuminated the genetic and environmental determinants of renal cell carcinoma susceptibility. Through large-scale genome-wide association studies conducted within European consortia, he has identified germline variants associated with RCC risk and investigated biomarker signatures in blood and tissue that distinguish early RCC from benign renal lesions.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
GWAS Identification of RCC Susceptibility Loci
Led genome-wide association studies within the International RCC Consortium identifying multiple novel germline susceptibility loci for clear cell and papillary RCC, implicating pathways including HIF signaling, DNA repair, and immune regulation in heritable kidney cancer risk.
Circulating Biomarkers for Early RCC Detection
Investigated metabolomic, proteomic, and cell-free DNA biomarkers in pre-diagnostic blood samples from prospective population cohorts, identifying candidate signatures that may enable earlier detection of RCC in high-risk populations.
Environmental and Lifestyle Risk Factors for RCC
Conducted comprehensive analyses of modifiable risk factors for RCC including obesity, hypertension, smoking, and occupational exposures using data from European prospective cohorts, quantifying attributable fractions and informing primary prevention strategies.
Hereditary RCC Syndromes: VHL and Beyond
Characterized the clinical and molecular features of hereditary RCC syndromes beyond VHL disease, including Birt-Hogg-Dubé syndrome, hereditary papillary RCC (HPRC), and SDH-deficient RCC, contributing to surveillance and management guidelines.
Representative Works 代表性著作
Genome-Wide Association Study Identifies Multiple Susceptibility Loci for Renal Cell Carcinoma
Nature Genetics (2019)
Large-scale GWAS meta-analysis identifying 13 novel susceptibility loci for RCC, substantially expanding the known genetic architecture of kidney cancer and implicating HIF-pathway genes in heritable risk.
Pre-Diagnostic Metabolomic Profiling and Renal Cell Carcinoma Risk
Journal of the National Cancer Institute (2021)
Prospective biomarker study identifying plasma metabolomic signatures associated with subsequent RCC diagnosis up to 10 years before clinical presentation in European prospective cohorts.
Modifiable Risk Factors for Renal Cell Carcinoma: A Systematic Review and Meta-Analysis
European Urology (2020)
Comprehensive meta-analysis quantifying the contribution of obesity, hypertension, smoking, and other modifiable factors to population-level RCC incidence, with implications for primary prevention.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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