Marko Markelc

Marko Markelc has developed intravital microscopy methods to visualize electroporation effects on tumor vasculature in real time, revealing the vascular disrupting mechanisms that contribute to electrochemotherapy efficacy. His imaging studies demonstrate that electric pulses cause rapid vasoconstriction, blood flow cessation, and endothelial cell death in tumor vessels, creating an antivascular effect that complements direct tumor cell killing. He connects electroporation biophysics with tumor biology through advanced imaging approaches.