Mark Rubin
马克·鲁宾
MD
Professor and Chair of Pathology, Director of Bern Center for Precision Medicine病理学教授兼主任，伯尔尼精准医学中心主任
👥Biography 个人简介
World-renowned prostate cancer pathologist who discovered the TMPRSS2:ERG fusion gene. Leads precision medicine initiatives combining digital pathology, spatial transcriptomics, and molecular biomarkers including AR splice variants and PTEN loss in prostate cancer.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
TMPRSS2:ERG Fusion Discovery
Co-discovered the TMPRSS2:ERG gene fusion in prostate cancer, the most common somatic rearrangement in this malignancy, opening new avenues for molecular diagnostics and targeted therapy development.
Digital Pathology Precision Medicine
Established integrated digital pathology and molecular profiling workflows at Bern enabling AI-assisted tumor characterization and spatial biomarker mapping for personalized treatment stratification.
Representative Works 代表性著作
Prostate Cancer Molecular Subtypes and Clinical Outcomes in the Digital Pathology Era
Nature Reviews Urology (2024)
Comprehensive review of molecular subtyping integrating genomics, transcriptomics, and digital pathology for precision prostate cancer management.
PTEN Loss and AR Splice Variant 7 Co-occurrence as Predictive Biomarkers of Enzalutamide Resistance
European Urology (2023)
Identified combined PTEN loss and AR-V7 as a biomarker signature predicting resistance to second-generation antiandrogen therapy.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Drew M. Pardoll
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Naiyer A. Rizvi
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