Mark Ratain
马克·拉坦
MD
Leon O. Jacobson Professor of Medicine; Director, Center for Personalized Therapeutics雅各布森医学讲席教授；个体化治疗中心主任
👥Biography 个人简介
Mark Ratain is a premier oncology pharmacologist who has challenged dogma in drug dosing and trial design. His advocacy for dose optimization and pragmatic trial approaches has saved costs and improved safety for cancer patients. He is a leading critic of suboptimal dose selection in oncology drug development.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Oncology Dose Optimization
Pioneered research demonstrating that many approved oncology drugs are used at unnecessarily high doses; advocated for dose-optimization studies as part of regulatory approval.
Pragmatic Clinical Trials in Oncology
Developed pragmatic trial designs that reduce barriers to participation and generate real-world relevant evidence for oncology drug approvals.
Pharmacogenomics and Personalized Dosing
Advanced use of pharmacogenomics to tailor drug doses to individual patients, reducing toxicity and improving outcomes in cancer pharmacotherapy.
Representative Works 代表性著作
Dose Optimization of Anticancer Agents: Are We Asking the Right Questions?
Nature Reviews Clinical Oncology (2021)
Influential critique arguing that oncology drug developers routinely select doses that are too high, causing unnecessary toxicity.
Sorafenib in Advanced Clear Cell Renal Cell Carcinoma: Pivotal Trial
New England Journal of Medicine (2007)
Co-authored registration trial for sorafenib, demonstrating improved progression-free survival in renal cell carcinoma.
UGT1A1 Genotyping and Irinotecan Dosing
Journal of Clinical Oncology (2004)
Established pharmacogenomic basis for individualizing irinotecan dosing, influencing FDA label revisions.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Naiyer A. Rizvi
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