Mark R. Middleton
马克·米德尔顿
PhD, FRCP
Professor of Experimental Cancer Medicine; Head, Oncology Department实验肿瘤医学教授；肿瘤科主任
👥Biography 个人简介
Mark Middleton, PhD, FRCP is Professor of Experimental Cancer Medicine at the University of Oxford and a key investigator in the development of tebentafusp, the first therapy to demonstrate overall survival benefit in metastatic uveal melanoma. His research program encompasses rare melanoma subtypes including uveal, acral, and mucosal melanoma, diseases with distinct biology and historically limited treatment options that differ fundamentally from cutaneous UV-driven melanoma.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Tebentafusp in Metastatic Uveal Melanoma
Key investigator on the IMCgp100-202 phase III trial of tebentafusp (a gp100xCD3 ImmTAC bispecific) versus investigator's choice, demonstrating the first overall survival benefit in metastatic uveal melanoma and supporting approval in HLA-A*02:01-positive patients.
Biology of Non-UV Melanoma Subtypes
Conducted translational studies characterizing the genomic and immunological landscape of acral and mucosal melanoma, informing rational treatment strategies for these UV-signature-negative subtypes with distinct driver mutations.
Early Phase Oncology Program at Oxford
Built and leads the Oxford experimental cancer medicine center, conducting first-in-human and early-phase trials of novel immunological agents across melanoma and solid tumors.
Representative Works 代表性著作
Tebentafusp versus investigator's choice in metastatic uveal melanoma (IMCgp100-202)
New England Journal of Medicine (2021)
Phase III trial demonstrating significantly improved overall survival with tebentafusp in HLA-A*02:01-positive metastatic uveal melanoma, the first survival benefit ever shown in this disease.
Genomic analysis of acral and mucosal melanoma
Cancer Research (2019)
Comprehensive genomic characterization of non-UV melanoma subtypes revealing distinct mutational spectra including KIT, NRAS, and CDK4 alterations relevant to therapeutic targeting.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-20 | All information from publicly available academic sources
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