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Translational Medicine / 转化医学TIL Therapy, Manufacturing

Mark Dudley

PhD

🏢National Cancer Institute / Iovance Biotherapeutics🌐USA

Former Head, Adoptive Cell Therapy Laboratory

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Key Contributions

👥Biography 个人简介

Dr. Mark Dudley developed the rapid expansion protocol (REP) for TIL manufacturing at the NCI's Surgery Branch, a landmark contribution that enabled large-scale ex vivo expansion of T cells for adoptive therapy. His work established the manufacturing framework that underpins current commercial TIL products. He subsequently transitioned to Iovance Biotherapeutics to apply these insights to commercial-scale GMP TIL manufacturing.

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🧪Research Fields 研究领域

rapid expansion protocol REP TIL
TIL manufacturing protocol standardization
lymphodepletion prior to TIL
IL-2 TIL expansion
TIL scale-up NCI Iovance

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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