John Marioni

John Marioni has developed foundational computational methods for single-cell RNA sequencing analysis including normalization, batch correction, and trajectory inference algorithms used across the cancer single-cell research community. His methods for integrating multi-modal single-cell data have enabled joint analysis of transcriptome, epigenome, and protein measurements from the same cancer cells. His computational frameworks have been essential for large-scale cancer atlas projects requiring integration of data from multiple laboratories and platforms.