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Cell Therapy / 细胞治疗CAR-T

Marcela V. Maus

M.D., Ph.D.

🏢Massachusetts General Hospital🌐USA

Director, Cellular Immunotherapy Program

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Key Papers
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Key Contributions

👥Biography 个人简介

Marcela Maus is a leader in developing CAR-T cell therapies for solid tumors, with particular focus on glioblastoma and other brain tumors. Her laboratory has pioneered local delivery of CAR-T cells to the central nervous system and developed novel CAR designs to overcome the immunosuppressive tumor microenvironment. Maus is advancing multiple CAR-T clinical trials at MGH.

Marcela Maus是开发实体肿瘤CAR-T细胞治疗的领导者,特别关注胶质母细胞瘤和其他脑肿瘤。她的实验室开创了CAR-T细胞向中枢神经系统的局部递送,并开发了克服免疫抑制性肿瘤微环境的新型CAR设计。Maus正在MGH推进多项CAR-T临床试验。

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🧪Research Fields 研究领域

CAR-T TherapyCAR-T治疗
Brain Tumor Immunotherapy脑肿瘤免疫治疗
Cell Engineering细胞工程

🎓Key Contributions 主要贡献

GBM CAR-T

Developing CAR-T approaches for glioblastoma with local CNS delivery.

CAR Engineering

Novel CAR designs incorporating safety switches and armoring strategies.

Representative Works 代表性著作

[1]

CAR T Cell Therapy for Glioblastoma: Lessons Learned from the First Clinical Trial

Clinical Cancer Research (2020)

Insights from first GBM CAR-T trial.

📄Data Sources 数据来源

Last updated: 2026-03-04 | All information from publicly available academic sources

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