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Translational Medicine / 转化医学Surrogate Endpoints, Clinical Trial Meta-analysis

Marc Buyse

ScD

🏢International Drug Development Institute🌐Belgium

Chief Scientific Officer

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Key Contributions

👥Biography 个人简介

Marc Buyse has made major contributions to the statistical validation of surrogate endpoints in oncology clinical trials — particularly validating whether progression-free survival (PFS) can serve as a reliable surrogate for overall survival (OS). His meta-analytic approaches for surrogate endpoint validation have informed regulatory decisions about acceptable endpoints for cancer drug approval and continue to be applied across multiple tumor types.

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🧪Research Fields 研究领域

surrogate endpoint validation cancer trials
progression-free survival overall survival surrogate
meta-analysis cancer clinical trials
clinical trial endpoint methodology
randomized controlled trial oncology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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