Marc Buyse
马克·布伊瑟
ScD
President and Chief Scientific Officer, IDDI; Professor of Biostatistics, Hasselt UniversityIDDI总裁兼首席科学官；哈瑟尔特大学生物统计学教授
👥Biography 个人简介
Marc Buyse, ScD is a world-leading biostatistician and the foremost authority on surrogate endpoint validation in oncology clinical trials. His meta-analytic frameworks for validating DFS, PFS, and tumor response as surrogates for overall survival have shaped global regulatory and trial design standards.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Surrogate Endpoint Validation in Oncology
Developed the two-stage meta-analytic validation framework for oncology surrogate endpoints, providing the statistical foundation used globally by regulatory agencies to accept DFS, PFS, and pCR as trial endpoints.
Individual Patient Data Meta-Analysis
Pioneered individual patient data meta-analysis methodology in oncology to robustly validate surrogate endpoints, improving rigor and reliability of endpoint selection in registration trials.
Representative Works 代表性著作
Validation of Surrogate Endpoints in Multiple Randomized Clinical Trials with Failure Time Endpoints
Journal of the Royal Statistical Society (2000)
Foundational statistical methodology for meta-analytic validation of surrogate endpoints in oncology, defining the Prentice criteria extensions widely used today.
Progression-Free Survival as a Surrogate for Overall Survival in Clinical Trials of Targeted and Biological Therapies
Annals of Oncology (2021)
Updated meta-analysis validating PFS as a surrogate for OS across modern targeted and immunotherapy oncology trials.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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