Manish Bhatt

Manish Bhatt leads clinical trials evaluating treatment de-escalation for HPV-positive oropharyngeal squamous cell carcinoma, which has excellent prognosis compared to HPV-negative disease. His research has examined reduced radiation dose, dose de-escalation approaches, and alternatives to cisplatin to achieve equivalent tumor control with less toxicity in this favorable-risk population. He has conducted the OPTIMA-II and related trials defining safe de-escalation strategies. His work addresses the critical challenge of right-sizing treatment intensity in highly curable HPV-positive head and neck cancer to reduce long-term morbidity.