Karl-Johan Malmberg

Karl-Johan Malmberg elucidated the mechanisms of NK cell education through KIR-HLA interactions, demonstrating that NK cell functional calibration is a continuous tuning process rather than a binary licensing event, with implications for optimizing NK cell therapy donor selection. His work on adaptive NK cell populations with enhanced ADCC capacity in CMV-seropositive individuals revealed novel effector populations for cancer immunotherapy exploitation. He leads clinical programs evaluating adoptive NK cell therapy with optimized KIR-HLA mismatch for hematologic malignancies.