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Translational Medicine / 转化医学Prostate Cancer, Enzalutamide

Maha Hussain

MD FACP FASCO

🏢Northwestern University Feinberg School of Medicine🌐USA

Genevieve E. Teuton Professor of Medicine and Deputy Director

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👥Biography 个人简介

Maha Hussain led the PREVAIL trial that established enzalutamide as a standard of care for metastatic castration-resistant prostate cancer and was pivotal in the AFFIRM trial. Her research has characterized androgen receptor pathway alterations that drive resistance to next-generation hormonal agents. She has contributed landmark studies on the biology of castration resistance and the role of AR splice variants in treatment failure. Her clinical trials work has fundamentally shaped the treatment of advanced prostate cancer.

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🧪Research Fields 研究领域

enzalutamide PREVAIL trial
castration-resistant prostate cancer
androgen receptor signaling
AR splice variants
hormonal therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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