Lynne I. Wagner
琳恩·瓦格纳
PhD
Professor of Social Sciences and Health Policy; Director, Oncology Patient-Reported Outcomes Program社会科学与健康政策教授；肿瘤患者报告结局项目主任
👥Biography 个人简介
Dr. Wagner is a leading expert on patient-reported outcomes (PROs) in oncology, directing research that integrates PRO measurement into clinical trials and practice. Her work on symptom burden, cognitive impairment, and emotional well-being has informed FDA guidance on PRO endpoints in cancer drug development.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
PRO Methodology in Oncology Trials
Advanced the science of patient-reported outcome measurement in cancer clinical trials, including cognitive function and depression endpoints now used in regulatory submissions.
Cognitive Impairment After Cancer Treatment
Led key studies characterizing cancer-related cognitive impairment (chemobrain) using validated PRO instruments, influencing survivorship care planning.
Distress and Symptom Integration
Developed models integrating distress screening with symptom cluster assessment to provide comprehensive psychosocial profiles for individualized care.
Representative Works 代表性著作
Patient-Reported Outcomes in Phase III Cancer Clinical Trials: Lessons Learned
Journal of Clinical Oncology (2015)
Outlined best practices for designing, analyzing, and reporting PRO data in phase III trials based on experience with NCI cooperative group studies.
Cognitive Function and Its Relationship to Other Cancer-Related Symptoms in Patients with Breast Cancer
Psycho-Oncology (2009)
Demonstrated that cognitive complaints co-occur with fatigue, depression, and sleep disturbance, highlighting the need for multisymptom intervention strategies.
Measuring Depression in Cancer Patients: A PRO Perspective
Journal of the National Cancer Institute Monographs (2007)
Provided regulatory-relevant guidance on selecting and validating depression measures for use as PRO endpoints in oncology clinical trials.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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