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Translational Medicine / 转化医学m6A in Leukemia Stem Cells, AML

Ly P. Vu

PhD

🏢Research Institute of Molecular Pathology (IMP), Vienna🌐Austria

Group Leader

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Key Contributions

👥Biography 个人简介

Ly P. Vu has demonstrated the critical role of m6A RNA methylation in maintaining leukemia stem cell identity and self-renewal. Her landmark study showed that genetic depletion of METTL3 induces differentiation and apoptosis in AML cells while sparing normal hematopoiesis, establishing the therapeutic window for targeting m6A writers. Her work has been foundational in advancing METTL3 inhibitors toward clinical development.

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🧪Research Fields 研究领域

m6A leukemia stem cells
METTL3 AML
RNA methylation self-renewal
leukemia differentiation
epitranscriptomic therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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