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Translational Medicine / 转化医学Biomarkers

Luis A. Diaz Jr.

M.D.

🏢Memorial Sloan Kettering Cancer Center🌐USA

Head, Division of Solid Tumor Oncology

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Key Papers
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Key Contributions

👥Biography 个人简介

Luis Diaz is a leader in precision oncology who discovered that mismatch repair deficiency (dMMR/MSI-H) predicts exceptional response to immune checkpoint inhibitors across tumor types. His work led to the first pan-cancer FDA approval of pembrolizumab for MSI-H tumors regardless of tissue origin—a landmark in precision medicine.

Luis Diaz是精准肿瘤学的领导者,他发现错配修复缺陷(dMMR/MSI-H)预测对免疫检查点抑制剂的卓越反应跨越肿瘤类型。他的工作导致了pembrolizumab针对MSI-H肿瘤的首个泛癌种FDA批准——精准医学的里程碑。

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🧪Research Fields 研究领域

Colorectal Cancer结直肠癌
MSI-H/dMMRMSI-H/dMMR
Liquid Biopsy液体活检

🎓Key Contributions 主要贡献

MSI-H Biomarker

Established MSI-H as pan-cancer predictive biomarker for checkpoint inhibitor response.

ctDNA Applications

Advanced circulating tumor DNA for cancer detection and monitoring.

Representative Works 代表性著作

[1]

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

New England Journal of Medicine (2015)

First demonstration of MSI-H as pan-cancer immunotherapy biomarker.

📄Data Sources 数据来源

Last updated: 2026-03-05 | All information from publicly available academic sources

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