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Translational Medicine / 转化医学Regulatory T Cells, CTLA-4 Trans-endocytosis
Lucy Walker
PhD
🏢University College London Institute of Immunity and Transplantation🌐UK
Professor of Immune Regulation
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Key Contributions
👥Biography 个人简介
Lucy Walker defined CTLA-4 trans-endocytosis as a core mechanism by which regulatory T cells remove B7 ligands from antigen-presenting cells to suppress immune responses. Her work clarified how anti-CTLA-4 therapies unleash antitumor immunity.
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🧪Research Fields 研究领域
CTLA-4 trans-endocytosis
Treg B7 ligand removal
CTLA-4 deficiency disease
mechanism of Treg suppression
follicular Treg
🎓Key Contributions 主要贡献
Representative Works 代表性著作
📄Data Sources 数据来源
Last updated: 2026-04-01 | All information from publicly available academic sources
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