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Translational Medicine / 转化医学Germline Predisposition, Myeloid Malignancies

Lucy Godley

MD PhD

🏢University of Chicago🌐USA

Professor

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Key Contributions

👥Biography 个人简介

Lucy Godley has contributed to understanding germline genetic predisposition to myeloid malignancies — demonstrating that a significant fraction of AML and MDS cases (~15-20% of older patients) carry pathogenic germline variants in RUNX1, DDX41, GATA2, CEBPA, and other myeloid predisposition genes. Her work establishing clinical evaluation and counseling frameworks for germline myeloid predisposition has important implications for family members at risk.

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🧪Research Fields 研究领域

germline predisposition myeloid cancer
DDX41 germline AML MDS
GATA2 germline syndrome
hereditary myeloid malignancy
RUNX1 germline cancer predisposition

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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