Luciano Martelotto

Luciano Martelotto is a single-cell epigenomics researcher in Australia whose work has advanced understanding of chromatin remodeling complex mutations in cancer. His research focused on ARID1A and SWI/SNF complex alterations in ovarian clear cell and endometrial cancers, identifying therapeutic vulnerabilities exposed by these mutations. He developed single-cell ATAC-seq approaches to map chromatin accessibility across tumor heterogeneity. His work provides mechanistic insights into how chromatin remodeling mutations drive cancer and can be therapeutically targeted.