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Translational Medicine / 转化医学Talquetamab, GPRC5DxCD3, Myeloma

Luciano Costa

MD, PhD

🏢University of Alabama at Birmingham🌐USA

Professor of Medicine

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Key Contributions

👥Biography 个人简介

Luciano Costa at UAB contributed to the clinical development of talquetamab (GPRC5D x CD3), a bispecific targeting the novel myeloma antigen GPRC5D. His work on the MonumenTAL trial demonstrated meaningful activity of talquetamab in heavily pre-treated myeloma, including patients refractory to BCMA-targeted therapies. He has investigated combination strategies using GPRC5D-targeting bispecifics with other myeloma agents. His research addresses sequencing bispecific antibodies and understanding GPRC5D antigen expression biology in myeloma.

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🧪Research Fields 研究领域

talquetamab GPRC5D
MonumenTAL trial myeloma
GPRC5D-targeted therapy
bispecific antibodies myeloma
multiple myeloma novel therapies

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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