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Translational Medicine / 转化医学Epigenetic Clock and Biological Aging

Ake Lu

PhD

🏢Altos Labs🌐USA

Research Scientist

32
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Key Contributions

👥Biography 个人简介

Ake Lu co-developed GrimAge, considered the most powerful epigenetic predictor of lifespan and cancer mortality, which uses DNA methylation surrogates of plasma proteins including PAI-1 and smoking pack-years. GrimAge has been validated across multiple cohorts as a superior predictor of time-to-cancer compared to first-generation clocks. His technical innovations in methylation-based plasma protein estimation have expanded the biomarker toolkit for cancer risk stratification.

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🧪Research Fields 研究领域

GrimAge clock
DNAm-based mortality predictor
Plasma protein-methylation surrogates
Smoking-aging-cancer nexus
Lifespan prediction

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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