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Translational Medicine / 转化医学DLBCL CAR-T and Bispecific Research

Frederick Locke

MD

🏢Moffitt Cancer Center🌐USA

Vice Chair and Associate Member, Department of Blood and Marrow Transplant

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👥Biography 个人简介

Frederick Locke is a leading CAR-T cell therapy investigator who has been central to the ZUMA program evaluating axicabtagene ciloleucel for DLBCL. His work advancing axi-cel to second-line treatment in the ZUMA-7 trial has changed the treatment paradigm for relapsed DLBCL. He has contributed extensively to understanding and managing CAR-T-associated neurotoxicity.

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🧪Research Fields 研究领域

Axi-cel development
ZUMA trials
CAR-T second line DLBCL
Real-world CAR-T outcomes
Neurotoxicity management

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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