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Translational Medicine / 转化医学Cancer Immunology, Tumor Antigens

Lloyd Old

MD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Distinguished Investigator (Deceased)

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Key Contributions

👥Biography 个人简介

Lloyd Old at MSK (1933-2011) was one of the founding fathers of modern cancer immunology. His discoveries include tumor necrosis factor (TNF), cancer-testis (CT) antigens — tumor-specific antigens not expressed in normal adult tissues — and his foundational research on cancer immunosurveillance, BCG as a cancer immunotherapy, and serological analysis of antigens by recombinant expression cloning (SEREX). His mentorship and advocacy for cancer immunology helped establish the field.

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🧪Research Fields 研究领域

tumor necrosis factor discovery
cancer-testis antigens CT antigens
tumor immunology foundational
BCG cancer immunotherapy
cancer immunosurveillance

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-03-01 | All information from publicly available academic sources

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