Livnat Jerby-Arnon

Livnat Jerby-Arnon has developed computational frameworks for systematic analysis of tumor ecosystems from single-cell data, identifying recurrent cancer cell programs associated with immune evasion, drug resistance, and metastatic potential across tumor types. Her work on pan-cancer single-cell meta-analysis has revealed that cancer cells across different tissues converge on shared transcriptional programs including a resistance program that predicts immunotherapy failure. She has mapped how interactions between cancer cells and their microenvironment shape therapeutic response at single-cell resolution. Her integrative approaches have identified new therapeutic targets by connecting cancer cell state programs to clinical outcomes.