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Translational Medicine / 转化医学KRAS G12C Later-Line Therapy

Piro Lito

MD, PhD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Associate Member

42
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Key Papers
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Key Contributions

👥Biography 个人简介

Piro Lito discovered the adaptive feedback reactivation mechanism that limits KRAS G12C inhibitor efficacy, defining the biological rationale for combination therapies. His laboratory research at MSKCC has identified SHP2 and SOS1 as key mediators of adaptive resistance. His work has directly informed clinical combination strategies in later-line settings.

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🧪Research Fields 研究领域

KRAS G12C
Adaptive resistance
RAS signaling
Cancer biology
Drug resistance mechanisms

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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