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Translational Medicine / 转化医学Lu-177 DOTATATE, Neuroendocrine Tumors

Lisa Bodei

MD, PhD

🏢Memorial Sloan Kettering Cancer Center🌐USA

Attending Physician, Molecular Imaging and Therapy Service

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Key Contributions

👥Biography 个人简介

Lisa Bodei is a world authority on peptide receptor radionuclide therapy (PRRT) for neuroendocrine tumors, having contributed to the NETTER-1 trial that demonstrated Lu-177 DOTATATE (Lutathera) significantly improves progression-free survival in midgut neuroendocrine tumors, leading to FDA approval. Her expertise in dosimetry-based treatment planning has established methods for personalizing PRRT dosing to maximize tumor-absorbed dose while protecting kidneys and bone marrow. She has extended PRRT approaches to additional somatostatin receptor-positive tumor types and is investigating combination strategies with targeted therapies. Her clinical research has defined the safety profile and long-term outcomes of radioligand therapy in neuroendocrine tumors.

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🧪Research Fields 研究领域

Lu-177 DOTATATE NETTER-1 trial NETs
peptide receptor radionuclide therapy PRRT
somatostatin receptor radioligand therapy
neuroendocrine tumor molecular imaging
radioligand therapy dosimetry renal toxicity

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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