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Translational Medicine / 转化医学RCC Belzutifan/HIF-2

W Marston Linehan

MD

🏢National Cancer Institute🌐USA

Chief, Urologic Oncology Branch

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Key Contributions

👥Biography 个人简介

Marston Linehan discovered the VHL gene and elucidated the VHL-HIF pathway that became the therapeutic target for belzutifan. His work on hereditary kidney cancer syndromes has identified multiple genes and pathways driving renal cell carcinoma. He is considered the father of kidney cancer genetics and his discoveries have directly enabled the development of HIF-2alpha inhibitors.

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🧪Research Fields 研究领域

VHL disease
Hereditary kidney cancer
HIF pathway
Renal cell carcinoma genetics
Metabolic oncology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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