Linda M. Liau
廖琳达
MD, PhD, MBA
Distinguished Professor and Chair, Department of Neurosurgery神经外科系主任杰出教授
👥Biography 个人简介
Chair of Neurosurgery at UCLA and pioneering researcher in brain tumor immunotherapy. Led the global phase III DCVax-L dendritic cell vaccine trial for GBM, demonstrating meaningful survival benefit in a subset of patients and opening a new era of active immunization strategies for brain cancers.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
DCVax-L Dendritic Cell Vaccine
Led the phase III DCVax-L trial showing dendritic cell immunotherapy extended median survival in newly diagnosed GBM with MGMT methylation, establishing a new personalized vaccine platform for brain tumors.
GBM Surgical and Immunological Research
Pioneered integration of intraoperative tumor sampling for immune profiling and personalized vaccine manufacturing, advancing translational pathways from surgery to immunotherapy.
Representative Works 代表性著作
Long-term survival of patients with glioblastoma treated with dendritic cell immunotherapy (DCVax-L)
JAMA Oncology (2023)
Phase III trial reporting 13.2-month median OS benefit in DCVax-L–treated MGMT-methylated GBM patients, the largest active immunotherapy trial in brain cancer.
Tumor-associated antigen expression in glioblastoma and its impact on immunotherapy response
Nature Cancer (2024)
Mechanistic study linking tumor antigen landscape to DCVax-L and checkpoint inhibitor outcomes in GBM patients.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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Drew M. Pardoll
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Naiyer A. Rizvi
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