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Translational Medicine / 转化医学Synthetic Biology and Engineered Immune Cells

Wendell Lim

PhD

🏢University of California San Francisco🌐USA

Professor of Cellular and Molecular Pharmacology

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Key Contributions

👥Biography 个人简介

Wendell Lim is the inventor of the synNotch receptor system that enables programming of multi-input logic-gated T cells for precise tumor targeting. His synthetic biology approach allows engineered immune cells to sense combinations of tumor antigens, reducing off-target toxicity while maintaining potent anti-cancer activity. His work has established the foundational paradigm for next-generation programmable cell therapies.

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🧪Research Fields 研究领域

SynNotch receptor engineering
Logic-gated CAR-T cells
Synthetic immunology
Cell circuit design
Programmable cell therapy

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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