Lillian Siu
萧丽莲
MD, FRCPC
Senior Medical Oncologist; Lead, Phase I Consortium; Co-Director, Drug Development Program高级肿瘤内科医生；I期联盟负责人；药物开发项目联合主任
👥Biography 个人简介
Lillian Siu is a leading figure in early-phase immuno-oncology trials and biomarker-driven drug development. She directs one of North America's premier phase I programs, has led pivotal early-phase trials of checkpoint inhibitors and novel immunotherapy combinations, and is a global authority on immunotherapy biomarkers.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Early-Phase Immunotherapy Trials
Led first-in-human and phase I/II trials of multiple PD-1/PD-L1 antibodies, LAG-3 inhibitors, and novel immune checkpoint combinations, shaping the clinical development of immuno-oncology agents.
Tumor Mutational Burden as Biomarker
Contributed foundational clinical evidence supporting tumor mutational burden (TMB) as a predictive biomarker for checkpoint inhibitor response across tumor types.
Head and Neck Immunotherapy
Conducted pivotal early clinical studies of immunotherapy in head and neck squamous cell carcinoma, establishing pembrolizumab and nivolumab as standard of care options.
Representative Works 代表性著作
Safety and Clinical Activity of Pembrolizumab for Treatment of Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
JAMA Oncology (2016)
Phase Ib KEYNOTE-012 data in HNSCC demonstrating pembrolizumab activity and establishing the basis for pivotal phase III trials.
Tumor Mutational Burden as a Predictive Biomarker in Solid Tumors Treated with Anti-PD-1/PD-L1 Therapy
Annals of Oncology (2019)
Comprehensive analysis supporting TMB as a pan-tumor predictive biomarker for checkpoint inhibitor benefit.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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关注 萧丽莲 的研究动态
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留下邮箱，当我们发布与 Lillian Siu（Princess Margaret Cancer Centre / University of Toronto）相关的新研究或访谈时，我们会通知你。
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