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Translational Medicine / 转化医学PI3K Pathway, Precision Oncology

Lewis Cantley

PhD

🏢Weill Cornell Medicine🌐USA

Director, Sandra and Edward Meyer Cancer Center

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Key Contributions

👥Biography 个人简介

Lewis Cantley at Weill Cornell Medicine discovered the PI3K enzyme in 1984, laying the groundwork for one of oncology's most important signaling pathways and drug target families. His foundational work on phosphoinositide 3-kinase led directly to the development of alpelisib, the first PI3Ka-specific inhibitor approved for PIK3CA-mutated breast cancer. He continues to study PI3K pathway biology and rational drug combination strategies to overcome resistance. He has been recognized with the Breakthrough Prize in Life Sciences for his contributions to cancer biology.

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🧪Research Fields 研究领域

PI3K discovery
PI3K pathway cancer
alpelisib PIK3CA breast cancer
AKT mTOR signaling
phosphoinositide signaling cancer

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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