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Translational Medicine / 转化医学Cell Therapy Manufacturing

Bruce Levine

PhD

🏢University of Pennsylvania🌐USA

Barbara and Edward Netter Professor in Cancer Gene Therapy

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Key Contributions

👥Biography 个人简介

Bruce Levine is a pioneering figure in CAR-T cell manufacturing who established the Clinical Cell and Vaccine Production Facility at the University of Pennsylvania, where the first FDA-approved CAR-T cell therapy tisagenlecleucel was manufactured. His work on scalable T cell expansion systems and GMP-compliant vector production has been foundational to the commercial viability of cell therapy products. He continues to advance decentralized and automated manufacturing platforms to improve patient access to cell therapies.

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🧪Research Fields 研究领域

CAR-T cell manufacturing
Clinical cell processing
GMP cell therapy production
Lentiviral vector manufacturing
T cell expansion technology

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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