Joseph Lehar

Joseph Lehar has developed influential mathematical frameworks for analyzing drug combination synergy in cancer, rigorously comparing the Loewe additivity and Bliss independence reference models and establishing best practices for quantifying synergy in the pharmaceutical drug development context. His work at Novartis has been foundational in establishing the computational methods used by the pharmaceutical industry for identifying and validating synergistic anti-cancer drug combinations in high-throughput screening programs. His synergy quantification methods have become industry standards for combination drug development.