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Translational Medicine / 转化医学NSCLC, EGFR T790M Resistance

Lecia V. Sequist

MD, MPH

🏢Massachusetts General Hospital, Harvard Medical School🌐USA

Professor of Medicine; Director, Center for Innovation in Early Cancer Detection

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Key Contributions

👥Biography 个人简介

Lecia Sequist is an internationally recognized thoracic oncologist whose research has defined the natural history of EGFR-mutant NSCLC under selective pressure from targeted therapies. She characterized the emergence and clinical significance of the T790M resistance mutation and contributed to development of osimertinib for T790M-positive disease. Her current work focuses on early cancer detection using liquid biopsy. She has mentored numerous investigators and leads national cooperative group studies.

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🧪Research Fields 研究领域

EGFR T790M
resistance mechanisms NSCLC
osimertinib second-line
EGFR natural history
lung cancer early detection

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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