Laura Esserman
劳拉·埃斯曼
MD, MBA
Professor of Surgery and Radiology; Director, UCSF Breast Care Center; I-SPY 2 Principal Investigator外科学与放射学教授；UCSF乳腺癌诊疗中心主任；I-SPY 2首席研究员
👥Biography 个人简介
Laura Esserman, MD MBA is a visionary surgical oncologist and the principal investigator of the I-SPY 2 Trial at UCSF, the world's most prominent adaptive neoadjuvant breast cancer platform trial. She champions transformative clinical trial innovation, integrating MRI biomarkers and molecular profiling to accelerate drug approval.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
I-SPY 2 Adaptive Platform Trial
Led I-SPY 2, a groundbreaking FDA-supported adaptive platform trial simultaneously evaluating multiple investigational agents in neoadjuvant breast cancer, using pathological complete response as a surrogate endpoint.
Neoadjuvant Trial Innovation
Pioneered the use of neoadjuvant therapy as a platform for rapid biomarker validation and drug evaluation, enabling multiple drugs to graduate to phase III trials based on adaptive Bayesian analysis.
Representative Works 代表性著作
Pathological Complete Response Predicts Long-Term Survival More Accurately than Does Recurrence Score in HER2-Positive Breast Cancer (I-SPY 2)
Journal of Clinical Oncology (2020)
Demonstrates pathological complete response as a robust surrogate for long-term survival in I-SPY 2 adaptive neoadjuvant trials.
Chemotherapy Response and Recurrence-Free Survival in Neoadjuvant HER2-Positive Breast Cancer with or without Pertuzumab (I-SPY 2)
JAMA Oncology (2021)
I-SPY 2 platform result showing superior outcomes with pertuzumab addition in HER2-positive subtypes using adaptive biomarker-based design.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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