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Translational Medicine / 转化医学ADC Payload Innovation

John Lambert

PhD

🏢ImmunoGen (Founder/Pioneer)🌐USA

Former Vice President, ADC Research

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👥Biography 个人简介

John Lambert is a founding figure in the antibody-drug conjugate field who developed maytansinoid payloads (DM1, DM4) that enabled ado-trastuzumab emtansine (T-DM1), the first approved ADC for solid tumors. His decades of work on conjugation chemistry and payload optimization established the scientific foundations for the modern ADC industry. His contributions have influenced virtually every subsequent ADC program.

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🧪Research Fields 研究领域

Maytansinoid payloads
DM1/DM4 chemistry
T-DM1 development
ADC conjugation chemistry
Antibody-drug conjugate founding

🎓Key Contributions 主要贡献

Representative Works 代表性著作

📄Data Sources 数据来源

Last updated: 2026-04-01 | All information from publicly available academic sources

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