Kristian Helin
克里斯蒂安·赫林
PhD
Chair, Cell Biology Program; Director, Center for Epigenetics Research细胞生物学项目主席；表观遗传学研究中心主任
👥Biography 个人简介
Kristian Helin is a pioneering figure in cancer epigenetics, having made seminal contributions to understanding EZH2 and Polycomb Repressive Complex 2 (PRC2) as oncogenic drivers. His work at MSK has defined multiple epigenetic vulnerabilities in cancer and advanced the development of several epigenetic drugs now in clinical use.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
EZH2 as an Oncogenic Driver
Demonstrated that EZH2 overexpression drives cancer by silencing tumor suppressor genes via H3K27me3, and that EZH2 gain-of-function mutations create neomorphic activity targeting specific loci to promote lymphomagenesis.
Histone Demethylase Function in Cancer
Discovered and characterized KDM family histone demethylases as tumor suppressors and oncoproteins, establishing that dynamic regulation of histone methylation is critical for maintaining normal gene expression programs.
Epigenetic Drug Target Validation
Systematically validated EZH2, LSD1, and JARID1 family members as drug targets using genetic and chemical tools, providing the mechanistic foundation for ongoing clinical trials of epigenetic inhibitors.
Representative Works 代表性著作
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation
Cancer Cell (2013)
Demonstrated that EZH2 is essential for germinal center B cells and that lymphoma-associated gain-of-function mutations promote transformation.
KDM2B links the Polycomb repressive complex 1 to recognition of CpG islands
Nature Genetics (2012)
Revealed that FBXL10/KDM2B recruits variant PRC1 to unmethylated CpG islands, establishing a methylation-sensing mechanism for Polycomb targeting.
The histone H3 lysine 27 demethylase JMJD3 links inflammation to inhibition of Polycomb-mediated gene silencing
Cell (2007)
Identified JMJD3 as the H3K27me3 demethylase linking inflammatory signals to activation of Polycomb-silenced genes.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
Related Experts 相关专家
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UCLA Jonsson Comprehensive Cancer Center
Drew M. Pardoll
Johns Hopkins University
Padmanee Sharma
MD Anderson Cancer Center
Naiyer A. Rizvi
Columbia University Irving Medical Center
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