Krishnansu S. Tewari
克里希南苏·特瓦里
MD
Professor and Director, Division of Gynecologic Oncology妇科肿瘤学部主任、教授
👥Biography 个人简介
Krishnansu S. Tewari, MD is a globally recognized leader in cervical cancer therapeutics at UC Irvine. He served as principal investigator of GOG0240, establishing bevacizumab plus chemotherapy as standard of care, and co-led KEYNOTE-826, incorporating pembrolizumab into first-line cervical cancer therapy, transforming outcomes for advanced disease.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
GOG0240: Bevacizumab in Cervical Cancer
PI of GOG0240, the landmark phase III trial demonstrating that adding bevacizumab to chemotherapy significantly improved overall survival in recurrent/metastatic cervical cancer, leading to FDA approval and establishing anti-angiogenic therapy as standard of care.
KEYNOTE-826: Pembrolizumab in First-Line Cervical Cancer
Co-led KEYNOTE-826, the phase III trial showing pembrolizumab combined with chemotherapy ± bevacizumab significantly improved PFS and OS in persistent, recurrent, or metastatic cervical cancer, defining a new immunotherapy-based standard of care.
Representative Works 代表性著作
Bevacizumab Combined with Chemotherapy for Cervical Cancer
New England Journal of Medicine (2014)
GOG0240 results establishing bevacizumab plus chemotherapy as first targeted therapy to improve survival in advanced cervical cancer.
Pembrolizumab plus Chemotherapy in Cervical Cancer (KEYNOTE-826)
New England Journal of Medicine (2021)
Phase III trial demonstrating survival benefit of pembrolizumab added to first-line chemotherapy ± bevacizumab in advanced cervical cancer.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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