Krishna V. Komanduri
克里希纳·科曼杜里
MD
Professor of Medicine; Director, UCSF Helen Diller Family Comprehensive Cancer Center BMT Program医学教授，UCSF海伦·迪勒家族综合癌症中心骨髓移植项目主任
👥Biography 个人简介
Krishna Komanduri is a translational immunologist and transplant physician whose research has illuminated the mechanisms of immune reconstitution after hematopoietic stem cell transplantation. His work defines how T-cell recovery shapes infection susceptibility, GvHD, and graft-versus-leukemia activity post-transplant.
🧪Research Fields 研究领域
🎓Key Contributions 主要贡献
Post-Transplant Immune Reconstitution
Characterized the kinetics and quality of T-cell reconstitution after allogeneic HSCT using advanced flow cytometry and functional assays, linking immune recovery to clinical outcomes.
CMV-Specific T-cell Immunity
Elucidated CMV-specific CD8+ T-cell responses post-transplant, providing mechanistic insight into susceptibility to viral reactivation and guiding immunotherapy strategies.
Immunologic Predictors of Transplant Outcome
Identified early immune reconstitution biomarkers predictive of relapse, GvHD, and infectious complications, enabling risk stratification for transplant patients.
Representative Works 代表性著作
Restoration of cytomegalovirus-specific CD4+ T-lymphocyte responses after ganciclovir and foscarnet therapy in individuals infected with HIV
Nature Medicine (1998)
Demonstrated restoration of virus-specific T-cell immunity with antiviral therapy, establishing principles applied to post-transplant CMV management.
Delayed immune reconstitution after cord blood transplantation is characterized by impaired thymopoiesis in association with prolonged inflammation
Blood (2007)
Revealed mechanisms underlying slow immune recovery after cord blood transplant, informing strategies to accelerate reconstitution.
CD4 cell counts and viral load among HIV-positive patients taking antiretroviral therapy in a large urban clinic
JAIDS (2001)
Provided population-level data linking immune parameters to HIV outcomes with implications for immunodeficiency management post-transplant.
🏆Awards & Recognition 奖项与荣誉
📄Data Sources 数据来源
Last updated: 2026-01-15 | All information from publicly available academic sources
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