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Translational Medicine / 转化医学HNSCC Systemic Therapy & European Clinical Research

Konstantinos N. Syrigos

康斯坦丁诺斯·西里戈斯

MD, PhD

🏢Athens School of Medicine, National and Kapodistrian University of Athens(雅典国立卡波季斯特里安大学医学院)🌐Greece

Professor of Medicine; Director, Oncology Unit, Sotiria Hospital, Athens医学教授,雅典索蒂里亚医院肿瘤科主任

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Key Contributions

👥Biography 个人简介

Konstantinos N. Syrigos, MD, PhD is Professor of Medicine and Director of the Oncology Unit at Sotiria Hospital, Athens, affiliated with the National and Kapodistrian University of Athens School of Medicine. He is one of the most prolific and internationally recognized oncology researchers in Greece, with extensive expertise in the medical treatment of head and neck squamous cell carcinoma (HNSCC) as well as lung cancer. Dr. Syrigos has been a principal investigator or co-investigator for numerous European and multinational clinical trials in HNSCC, contributing patient cohorts and scientific expertise to studies of platinum-based chemotherapy, cetuximab-containing regimens, and, more recently, PD-1/PD-L1 checkpoint inhibitors. He has authored over 400 peer-reviewed publications and has been consistently ranked among the top-cited researchers in oncology from southeastern Europe. Dr. Syrigos has contributed to the clinical pharmacology of anticancer drugs in HNSCC and is known for translational studies examining predictive biomarkers including EGFR expression levels, K-RAS mutations, and tumor PD-L1 in the context of systemic therapies. He is a member of multiple ESMO and ASCO committees and serves on the editorial boards of leading oncology journals.

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🧪Research Fields 研究领域

HNSCC Systemic and Multimodal TherapyHNSCC系统性及多模式治疗
Platinum-Based Chemotherapy in HNSCCHNSCC铂类化疗
EGFR Inhibitors in Head and Neck Cancer头颈部癌症EGFR抑制剂
Immunotherapy in Recurrent/Metastatic HNSCC复发/转移性HNSCC免疫治疗
Lung Cancer and HNSCC Dual Expertise肺癌与HNSCC双重专业知识

🎓Key Contributions 主要贡献

HNSCC Systemic Therapy — Multicentre Trial Participation

Served as principal investigator for Sotiria Hospital's participation in major multinational HNSCC trials examining platinum-based chemotherapy combinations, cetuximab regimens, and checkpoint inhibitors, contributing patient accrual and data to practice-changing studies.

Biomarker Studies in EGFR-Targeted HNSCC Therapy

Conducted translational analyses correlating EGFR gene copy number, protein expression levels, and downstream signaling pathway activation with outcomes in HNSCC patients receiving cetuximab-based treatment, contributing to understanding of predictive factors for EGFR inhibitor benefit.

Immunotherapy in Recurrent/Metastatic HNSCC — Greek Population Studies

Led clinical investigations of pembrolizumab and nivolumab in Greek HNSCC patients, characterizing real-world treatment patterns, outcomes, and tolerability in a southeastern European population, with attention to differences in patient characteristics including HPV prevalence relative to Western European cohorts.

Platinum-Based Chemotherapy Optimization in HNSCC

Contributed clinical research and review analyses on optimal platinum-based chemotherapy regimens for locally advanced and recurrent/metastatic HNSCC, including carboplatin versus cisplatin comparisons, dose optimization, and management of chemotherapy-associated toxicities.

Representative Works 代表性著作

[1]

Cetuximab with or without gemcitabine for platinum-refractory recurrent and/or metastatic squamous cell carcinoma of the head and neck

Cancer Chemotherapy and Pharmacology (2015)

Phase II trial of cetuximab ± gemcitabine in platinum-refractory R/M HNSCC reporting activity and tolerability in a predominantly European patient population.

[2]

The role of pembrolizumab in recurrent and/or metastatic head and neck squamous cell carcinoma

Expert Review of Anticancer Therapy (2020)

Comprehensive expert review of pembrolizumab clinical trial data and practical implementation in R/M HNSCC including biomarker selection strategies.

[3]

Systematic review of immunotherapy with anti-PD-1/PD-L1 in head and neck cancers

Critical Reviews in Oncology/Hematology (2019)

Systematic review summarizing the clinical evidence base for anti-PD-1/PD-L1 therapy across HNSCC subsites including oropharynx, larynx, and hypopharynx.

[4]

Epidermal growth factor receptor expression in head and neck cancer: a review of the literature

Cancer Treatment Reviews (2004)

Widely cited review establishing the prevalence, prognostic significance, and therapeutic implications of EGFR overexpression across HNSCC anatomic subsites.

🏆Awards & Recognition 奖项与荣誉

🏆Hellenic Society of Medical Oncology (HeSMO) President
🏆ESMO Faculty Member — Head and Neck Oncology
🏆European Respiratory Society Distinguished Membership
🏆University of Athens Award for Excellence in Medical Research

📄Data Sources 数据来源

Last updated: 2026-04-06 | All information from publicly available academic sources

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